Off-Label Use of Pharmaceuticals: Trends and Drivers
نویسندگان
چکیده
We identify the rate of off-label use of prescription drugs in the United States during 1993-2008. We apply Detection Controlled Estimation to a comprehensive crosssection of prescriptions and find that rates of off-label use rise from 30.2% to 39.1% during this period. This coincides with a surge in settlements of Department of Justice lawsuits for off-label marketing. Additionally, physicians are more likely to prescribe off-label when there are fewer FDA-approved alternatives and when a patient’s insurance has less restrictive formularies and lower copayments. These substitution patterns are consistent with off-label prescribing by physicians that enhances the welfare of patients. JEL Code: L51, I10, I18, I13, K23
منابع مشابه
General Assessment Of Unlicensed Medicine Usage In Turkey.
Pharmaceuticals can be used in un-approved or unlicensed indications or dosages apart from their licensed use. This is called off-label use. In principle, a drug can be considered to be off label under three conditions: (i) if the approval have not been extended, although evidence of efficacy is available; (ii) if it falls into the so-called ‘grey zone’ of evidence-based medicine, within which ...
متن کاملOff-label use of drugs in children.
The passage of the Best Pharmaceuticals for Children Act and the Pediatric Research Equity Act has collectively resulted in an improvement in rational prescribing for children, including more than 500 labeling changes. However, off-label drug use remains an important public health issue for infants, children, and adolescents, because an overwhelming number of drugs still have no information in ...
متن کاملWhen Are Medical Apps Medical? Off-Label Use and the Food and Drug Administration
People have a love/hate relationship with rapidly changing healthcare technology. While consumer demand for medical apps continues to grow as rapidly as does supply (there are over 100,000 health, wellness and medical applications, or ‘apps’ on the market), healthcare professionals and safety experts worry about the impact of these apps on the health consumer. In response to the rapidly growing...
متن کاملReview Study: Intravenous Thrombolysis, Time Window, Dosage, and Off-Label
Despite the development of Intravenous thrombolysis with tissue Plasminogen Activator (IVtPA) guidelines in each affiliated stroke center, protocol violations may be observed in each hospital with IVtPA facilities. An extensive search of scientific electronic databases including PubMed, OVID, Index Medicus, Index Copernicus, Google, ISI, and Scopus was performed with keywords of Thrombolysis, O...
متن کاملCongestion Pricing: A Parking Queue Model
Drivers in urban neighborhoods who patrol streets, seeking inexpensive on-street parking create a significant fraction of measured traffic congestion. The pool of drivers patrolling at any time can be modeled as a queue, where ‘queue service’ is the act of parking in a recently vacated parking space and queue discipline is SIRO – Service In Random Order. We develop a queueing model of such driv...
متن کامل